Isabelle Bos; Stephanie J. B. Vos; Frans Verhey; Philip Scheltens; Charlotte E. Teunissen; Sebastiaan Engelborghs; Kristel Sleegers; Giovanni B. Frisoni; Olivier Blin; Jill Richardson; Régis Bordet; Magda Tsolaki; Julius Popp; Gwendoline Peyratout; Pablo Martínez‐Lage; Mikel Tainta; Alberto Lleó; Peter Johannsen; Yvonne Freund‐Levi; Lutz Frölich; Rik Vandenberghe; Sarah Westwood; Valerija Dobričić; Frederik Barkhof; Cristina Legido‐Quigley; Lars Bertram; Simon Lovestone; Johannes Streffer; Ulf Andréasson; Kaj Blennow; Henrik Zetterberg; Pieter Jelle Visser · 2019 · Alzheimer s & Dementia
Paper
INTRODUCTION: We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). METHODS: We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with Aβ status (Aβ- vs. Aβ+), clinical diagnosis APOE ε4 carriership, baseline cognition, and change in cognition. RESULTS: Ng and T-tau distinguished between Aβ+ from Aβ- individuals in each clinical group, whereas NFL and YKL-40 were associated with Aβ+ in nondemented individuals only. APOE ε4 carriership did not influence NFL, Ng, and YKL-40 in Aβ+ individuals. NFL was the best predictor of cognitive decline in Aβ+ individuals across the cognitive spectrum. DISCUSSION: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker.
Analysis
This study examined cerebrospinal fluid (CSF) biomarkers (neurogranin, neurofilament light, YKL-40, and total tau) in relation to amyloid-beta status, APOE ε4, and cognition across the Alzheimer's disease spectrum, finding that Ng and T-tau differentiate amyloid status, while NFL predicts cognitive decline.
Discovery
Dietmar Rudolf Thal; Koen Poesen; Rik Vandenberghe; Steffi De Meyer
Nicholas J. Ashton; Wagner S. Brum; Guglielmo Di Molfetta; Andréa Lessa Benedet; Burak Arslan; Erin M. Jonaitis; Rebecca E. Langhough; Karly Alex Cody; Rachael E. Wilson; Cynthia M. Carlsson; Eugeen Vanmechelen; Laia Montoliu‐Gaya; Juan Lantero‐Rodriguez; Nesrine Rahmouni; Cécile Tissot; Jenna Stevenson; Stijn Servaes; Joseph Therriault; Tharick A. Pascoal; Alberto Lleó; Daniel Alcolea; Juan Fortea; Pedro Rosa‐Neto; Sterling C. Johnson; Andreas Jeromin; Kaj Blennow; Henrik Zetterberg
Charles Bernick; Guogen Shan; Aaron Ritter; Nicholas J. Ashton; Kaj Blennow; Juan Lantero‐Rodriguez; Anniina Snellman; Henrik Zetterberg
Fernando González‐Ortiz; Michael Turton; Przemysław R. Kac; Denis S. Smirnov; Enrico Premi; Roberta Ghidoni; Luisa Benussi; Valentina Cantoni; Claudia Saraceno; Jasmine Rivolta; Nicholas J. Ashton; Barbara Borroni; Douglas Galasko; Peter Harrison; Henrik Zetterberg; Kaj Blennow; Thomas K. Karikari
Oskar Hansson; Rebecca M. Edelmayer; Adam L. Boxer; María C. Carrillo; Michelle M. Mielke; Gil D. Rabinovici; Stephen Salloway; Reisa A. Sperling; Henrik Zetterberg; Charlotte E. Teunissen
Henrik Zetterberg; Kaj Blennow
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