Anbiao Wu; Jiyan Zhang · 2023 · Journal of Neuroinflammation
Paper
Abstract As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of premature death and other medical conditions for patients. Neuroinflammation is the abnormal immune response in the brain, and its correlation with MDD is receiving increasing attention. Neuroinflammation has been reported to be involved in MDD through distinct neurobiological mechanisms, among which the dysregulation of neurogenesis in the dentate gyrus (DG) of the hippocampus (HPC) is receiving increasing attention. The DG of the hippocampus is one of two niches for neurogenesis in the adult mammalian brain, and neurotrophic factors are fundamental regulators of this neurogenesis process. The reported cell types involved in mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, and peripheral immune cells which selectively penetrate the blood–brain barrier and infiltrate into inflammatory regions. This review summarizes the functions of the hippocampus affected by neuroinflammation during MDD progression and the corresponding influences on the memory of MDD patients and model animals.
Analysis
This review explores the link between neuroinflammation, major depressive disorder (MDD), and hippocampal neurogenesis, focusing on its impact on memory.
Discovery
John Chulhoon Park; Leechung Chang; Ho‐Keun Kwon; Sin‐Hyeog Im
Kenneth J. O’Riordan; Gerard M. Moloney; Lily Keane; Gerard Clarke; John F. Cryan
Renqing Zhao
Echo Yongqi Luo; Rio Ryohichi Sugimura
Weifeng Zhang; Dan Xiao; Qinwen Mao; Haibin Xia
Eduardo Candelario‐Jalil; Rick M. Dijkhuizen; Tim Magnus
Source record