Ben A Meinen; Christopher D Bahl · 2021 · Protein Engineering, Design and Selection
Paper
Abstract Proteins catalyze the majority of chemical reactions in organisms, and harnessing this power has long been the focus of the protein engineering field. Computational protein design aims to create new proteins and functions in silico, and in doing so, accelerate the process, reduce costs and enable more sophisticated engineering goals to be accomplished. Challenges that very recently seemed impossible are now within reach thanks to several landmark advances in computational protein design methods. Here, we summarize these new methods, with a particular emphasis on de novo protein design advancements occurring within the past 5 years.
Analysis
This paper reviews recent advances in computational protein design, focusing on de novo engineering methods developed in the last five years that are accelerating the creation of novel proteins with desired functions.
Discovery
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