Chen P; Yue T; Shi D; Bi X; Zhang W; Wu Z; Zheng C · 2026 · Frontiers in oncology
Paper
Gastric metastases are rare, accounting for only 0.2%-0.7% of gastric malignancies. Gastric metastasis from primary popliteal fossa leiomyosarcoma (LMS) has not been previously reported. We report a 60-year-old female who presented with hematemesis and severe anemia, with a past medical history of right popliteal fossa LMS resection. Imaging and endoscopy revealed a bleeding nodular lesion in the gastric body. Pathology and immunohistochemistry (SMA+/Desmin+, CD117-/DOG-1-) confirmed metastatic LMS to the stomach, with suspected pancreatic and bone metastases. The patient underwent emergency embolization for active bleeding, followed by laparoscopic partial gastrectomy and systemic chemotherapy. At the 9-month follow-up, she remained in good general condition. This case highlights that in patients with a history of malignancy presenting with gastrointestinal bleeding, gastric metastasis should be considered, and multidisciplinary management combined with surgery and systemic therapy can achieve favorable outcomes.
Analysis
This case report details the rare occurrence of a popliteal leiomyosarcoma metastasizing to the stomach, emphasizing the importance of considering metastatic disease in patients with a history of malignancy presenting with gastrointestinal bleeding.
Discovery
Zhang JS; Ng JCK; Hermida de Viveiros P; Al-Marayaty R; Al Akoum N; Shinglot H; Jing W; Vizcaino V; Alexiev BA; Cranmer LD; Loggers ET; Abrams H; Wagner MJ; Pillarisetty VG; Kim EY; Pierce RH; Berglund P; Jones RL; Lu H; Ter Meulen J; Pollack SM; Seo YD
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