Noopur Raje; Jesús G. Berdeja; Yi Lin; David S. Siegel; Sundar Jagannath; Deepu Madduri; Michaela Liedtke; Jacalyn Rosenblatt; Marcela V. Maus; Ashley Turka; Lyh-Ping Lam; Richard A. Morgan; Kevin M. Friedman; Monica Massaro; Julie Wang; Greg Russotti; Zhihong Yang; Timothy Campbell; Kristen Hege; Fabio Petrocca; M. Travis Quigley; Nikhil C. Munshi; James N. Kochenderfer · 2019 · New England Journal of Medicine
Paper
BACKGROUND: Preclinical studies suggest that bb2121, a chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA), has potential for the treatment of multiple myeloma. METHODS: CAR+ T cells in the expansion phase. Patients had received at least three previous lines of therapy, including a proteasome inhibitor and an immunomodulatory agent, or were refractory to both drug classes. The primary end point was safety. RESULTS: nucleated cells). CAR T-cell expansion was associated with responses, and CAR T cells persisted up to 1 year after the infusion. CONCLUSIONS: We report the initial toxicity profile of a BCMA-directed cellular immunotherapy for patients with relapsed or refractory multiple myeloma. Antitumor activity was documented. (Funded by Bluebird Bio and Celgene; CRB-401 ClinicalTrials.gov number, NCT02658929.).
Analysis
This study reports the initial safety and antitumor activity of bb2121, a BCMA-targeted CAR T-cell therapy, in patients with relapsed or refractory multiple myeloma.
Discovery
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