Oskar Hansson; Rebecca M. Edelmayer; Adam L. Boxer; María C. Carrillo; Michelle M. Mielke; Gil D. Rabinovici; Stephen Salloway; Reisa A. Sperling; Henrik Zetterberg; Charlotte E. Teunissen · 2022 · Alzheimer s & Dementia
Paper
Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD pathological changes for inclusion in trials evaluating disease-modifying therapies, provided the AD status is confirmed with positron emission tomography (PET) or cerebrospinal fluid (CSF) testing. We also encourage studying longitudinal BBM changes in ongoing as well as future interventional trials. However, BBMs should not yet be used as primary endpoints in pivotal trials. Further, we recommend to cautiously start using BBMs in specialized memory clinics as part of the diagnostic work-up of patients with cognitive symptoms and the results should be confirmed whenever possible with CSF or PET. Additional data are needed before use of BBMs as stand-alone diagnostic AD markers, or before considering use in primary care.
Analysis
This paper outlines recommendations for the use of blood-based biomarkers in Alzheimer's disease, suggesting their role in screening for clinical trials and in specialized memory clinics, while emphasizing the need for further research before widespread standalone diagnostic use.
Discovery
Dietmar Rudolf Thal; Koen Poesen; Rik Vandenberghe; Steffi De Meyer
Nicholas J. Ashton; Wagner S. Brum; Guglielmo Di Molfetta; Andréa Lessa Benedet; Burak Arslan; Erin M. Jonaitis; Rebecca E. Langhough; Karly Alex Cody; Rachael E. Wilson; Cynthia M. Carlsson; Eugeen Vanmechelen; Laia Montoliu‐Gaya; Juan Lantero‐Rodriguez; Nesrine Rahmouni; Cécile Tissot; Jenna Stevenson; Stijn Servaes; Joseph Therriault; Tharick A. Pascoal; Alberto Lleó; Daniel Alcolea; Juan Fortea; Pedro Rosa‐Neto; Sterling C. Johnson; Andreas Jeromin; Kaj Blennow; Henrik Zetterberg
Charles Bernick; Guogen Shan; Aaron Ritter; Nicholas J. Ashton; Kaj Blennow; Juan Lantero‐Rodriguez; Anniina Snellman; Henrik Zetterberg
Fernando González‐Ortiz; Michael Turton; Przemysław R. Kac; Denis S. Smirnov; Enrico Premi; Roberta Ghidoni; Luisa Benussi; Valentina Cantoni; Claudia Saraceno; Jasmine Rivolta; Nicholas J. Ashton; Barbara Borroni; Douglas Galasko; Peter Harrison; Henrik Zetterberg; Kaj Blennow; Thomas K. Karikari
Henrik Zetterberg; Kaj Blennow
Henry Querfurth; Han-Kyu Lee
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