Tingting Wang; Dangge Wang; Haijun Yu; Bing Feng; Fangyuan Zhou; Hanwu Zhang; Lei Zhou; Shi Jiao; Yaping Li · 2018 · Nature Communications
Paper
Vaccines to induce effective and sustained antitumor immunity have great potential for postoperative cancer therapy. However, a robust cancer vaccine simultaneously eliciting tumor-specific immunity and abolishing immune resistance continues to be a challenge. Here we present a personalized cancer vaccine (PVAX) for postsurgical immunotherapy. PVAX is developed by encapsulating JQ1 (a BRD4 inhibitor) and indocyanine green (ICG) co-loaded tumor cells with a hydrogel matrix. Activation of PVAX by 808 nm NIR laser irradiation significantly inhibits the tumor relapse by promoting the maturation of dendritic cells and eliciting tumor infiltration of cytotoxic T lymphocytes. A mechanical study reveals that NIR light-triggered antigen release and JQ1-mediated PD-L1 checkpoint blockade cumulatively contribute to the satisfied therapeutic effect. Furthermore, PVAX prepared from the autologous tumor cells induces patient-specific memory immune response to prevent tumor recurrence and metastasis. The PVAX model might provide novel insights for postoperative immunotherapy.
Analysis
This paper presents a personalized cancer vaccine (PVAX) that uses encapsulated JQ1 and indocyanine green (ICG) co-loaded tumor cells within a hydrogel matrix, activated by NIR laser irradiation, to inhibit tumor relapse and prevent recurrence and metastasis.
Discovery
Ruby Srivastava
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