Microfluidic Organ-on-a-Chip Models of Human Intestine

Amir Bein; Woojung Shin; Sasan Jalili‐Firoozinezhad; Min Hee Park; Alexandra Sontheimer-Phelps; Alessio Tovaglieri; Angeliki Chalkiadaki; Hyun Jung Kim; Donald E. Ingber · 2018 · Cellular and Molecular Gastroenterology and Hepatology

Paper

Abstract

Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we review this field and describe how microfluidic Intestine Chips offer new capabilities not possible with conventional culture systems or organoid cultures, including the ability to analyze contributions of individual cellular, chemical, and physical control parameters one-at-a-time; to coculture human intestinal cells with commensal microbiome for extended times; and to create human-relevant disease models. We also discuss potential future applications of human Intestine Chips, including how they might be used for drug development and personalized medicine.

Analysis

Paper intelligence

Summary

This review details the development and capabilities of microfluidic Intestine Chips as advanced in vitro models for studying human intestinal physiology, pathophysiology, and disease.

Key findings

Microfluidic Intestine Chips offer capabilities beyond conventional culture systems and organoids.
These chips allow for single-parameter analysis (cellular, chemical, physical).
Human intestinal cells can be co-cultured with commensal microbiome for extended periods.
Human-relevant disease models can be created.

Methods

Development of microfluidic organ-on-a-chip models of human intestine.

Limitations

Not explicitly detailed in the abstract, but implied by the focus on advanced capabilities.

Applications

Studying intestinal physiology and pathophysiology.
Drug development.
Personalized medicine.
Co-culturing with microbiome.
Creating disease models.

Confidence100%

Discovery

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Source record

Publication metadata

Authors: Amir Bein; Woojung Shin; Sasan Jalili‐Firoozinezhad; Min Hee Park; Alexandra Sontheimer-Phelps; Alessio Tovaglieri; Angeliki Chalkiadaki; Hyun Jung Kim; Donald E. Ingber
Published: Jan 1, 2018
Journal or venue: Cellular and Molecular Gastroenterology and Hepatology
DOI: 10.1016/j.jcmgh.2017.12.010
Paper type: journal article
Source: Openalex

DOI OpenAlex