Giovanna Maria Stanfoca Casagrande; Marcela de Oliveira Silva; Rui Manuel Reis; Letícia Ferro Leal · 2023 · International Journal of Molecular Sciences
Paper
Lung cancer is the deadliest cancer worldwide. Tissue biopsy is currently employed for the diagnosis and molecular stratification of lung cancer. Liquid biopsy is a minimally invasive approach to determine biomarkers from body fluids, such as blood, urine, sputum, and saliva. Tumor cells release cfDNA, ctDNA, exosomes, miRNAs, circRNAs, CTCs, and DNA methylated fragments, among others, which can be successfully used as biomarkers for diagnosis, prognosis, and prediction of treatment response. Predictive biomarkers are well-established for managing lung cancer, and liquid biopsy options have emerged in the last few years. Currently, detecting EGFR p.(Tyr790Met) mutation in plasma samples from lung cancer patients has been used for predicting response and monitoring tyrosine kinase inhibitors (TKi)-treated patients with lung cancer. In addition, many efforts continue to bring more sensitive technologies to improve the detection of clinically relevant biomarkers for lung cancer. Moreover, liquid biopsy can dramatically decrease the turnaround time for laboratory reports, accelerating the beginning of treatment and improving the overall survival of lung cancer patients. Herein, we summarized all available and emerging approaches of liquid biopsy-techniques, molecules, and sample type-for lung cancer.
Analysis
This review explores the utility of liquid biopsy in lung cancer, detailing its minimally invasive approach for diagnosis, prognosis, and treatment monitoring using various biomarkers and its potential to accelerate treatment and improve survival.
Discovery
Hyukjung Kwon; Sun Hye Shin; Hyun Ho Kim; Na Young Min; Yugyeong Lim; T. Joo; Kyoung Joo Lee; Minseon Jeong; Hyojung Kim; Seon-young Yun; Yoon-Hee Kim; Dabin Park; Joungsu Joo; Jin‐Sik Bae; Sunghoon Lee; Byeong‐Ho Jeong; Kyungjong Lee; Hayemin Lee; Hong Kwan Kim; Kyongchol Kim; Sang‐Won Um; Changhyeok An; Min Seob Lee
Christopher Abbosh; Alexander M. Frankell; Thomas Harrison; Judit Kisistók; Aaron T. Garnett; Laura Johnson; Selvaraju Veeriah; Mike Moreau; Adrian Chesh; Tafadzwa L. Chaunzwa; Jakob Weiss; Morgan R. Schroeder; Sophia Ward; Kristiana Grigoriadis; Aamir Shahpurwalla; Kevin Litchfield; Clare Puttick; Dhruva Biswas; Takahiro Karasaki; James R. Black; Carlos Martínez‐Ruiz; Maise Al Bakir; Oriol Pich; Thomas B.K. Watkins; Emilia L. Lim; Ariana Huebner; David A. Moore; Nadia Godin-Heymann; Anne L’Hernault; Hannah Bye; Aaron Odell; Paula Kalavakur; Fábio Gomes; Akshay J. Patel; Elizabeth Manzano; Crispin T. Hiley; Nicolas Carey; Joan Riley; Daniel E. Cook; Darren Hodgson; Daniel Stetson; J. Carl Barrett; Roderik M. Kortlever; Gérard I. Evan; Allan Hackshaw; Robert Daber; Jacqui Shaw; Hugo J.W.L. Aerts; Abel Licon; Josh Stahl; Mariam Jamal‐Hanjani; J.F. Lester; Amrita Bajaj; Apostolos Nakas; Azmina Sodha-Ramdeen; Keng Ang; Mohamad Tufail; Mohammed Fiyaz Chowdhry; Molly Scotland; Rebecca Boyles; Sridhar Rathinam; Claire Wilson; Domenic Marrone; Sean Dulloo; Dean A. Fennell; Gurdeep Matharu; Lindsay Primrose; Ekaterini Boleti; Heather Cheyne; Mohammed S. Khalil; Shirley Richardson; Tracey Cruickshank; Gillian Price; Keith M. Kerr; Sarah Benafif; Kayleigh Gilbert; Babu Naidu; Aya Osman; Christer Lacson; Gerald Langman; Helen Shackleford; Madava Djearaman; Salma Kadiri; Gary Middleton; Angela Leek; Jack Davies Hodgkinson; Nicola Totten; Ángeles Montero; Elaine Smith; Eustace Fontaine; Felice Granato; Helen Doran; Juliette Novasio; Kendadai Rammohan; Leena Dennis Joseph; Paul Bishop; Rajesh Shah; Stuart Moss; Vijay Joshi; Philip Crosbie
Siobhan Connal; James M. Cameron; Alexandra Sala; Paul M. Brennan; David Scott Palmer; Joshua D. Palmer; Haley K. Perlow; Matthew J. Baker
Saife N. Lone; Sabah Nisar; Tariq Masoodi; Mayank Singh; Arshi Rizwan; Sheema Hashem; Wael El‐Rifai; Davide Bedognetti; Surinder K. Batra; Mohammad Haris; Ajaz A. Bhat; Muzafar A. Macha
David L. Crosby; Sangeeta N. Bhatia; Kevin M. Brindle; Lisa M. Coussens; Caroline Dive; Mark Emberton; Sadik C. Esener; Rebecca C. Fitzgerald; Sanjiv S. Gambhir; Peter Kühn; Timothy R. Rebbeck; Shankar Balasubramanian
Dan Yu; Yixin Li; Maoye Wang; Jianmei Gu; Wenrong Xu; Hui Cai; Xinjian Fang; Xu Zhang
Source record