Yu Shrike Zhang; Julio Aleman; Su Ryon Shin; Tuğba Kiliç; Duck Jin Kim; Seyed Ali Mousavi Shaegh; Solange Massa; Reza Riahi; Sukyoung Chae; Ning Hu; Hüseyin Avcı; Weijia Zhang; Antonia Silvestri; Amir Sanati‐Nezhad; Ahmad Manbohi; Fabio De Ferrari; Alessandro Polini; Giovanni Calzone; Noor Shaikh; Parissa Alerasool; Erica Budina; Jian Kang; Nupura Bhise; João Ribas; Adel Pourmand; Aleksander Skardal; Thomas Shupe; Colin E. Bishop; Mehmet R. Dokmeci; Anthony Atala; Ali Khademhosseini · 2017 · Proceedings of the National Academy of Sciences
Paper
Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models designed to recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These in vitro models, featuring biomimetic compositions, architectures, and functions, are expected to replace the conventional planar, static cell cultures and bridge the gap between the currently used preclinical animal models and the human body. Multiple organoid models may be further connected together through the microfluidics in a similar manner in which they are arranged in vivo, providing the capability to analyze multiorgan interactions. Although a wide variety of human organ-on-a-chip models have been created, there are limited efforts on the integration of multisensor systems. However, in situ continual measuring is critical in precise assessment of the microenvironment parameters and the dynamic responses of the organs to pharmaceutical compounds over extended periods of time. In addition, automated and noninvasive capability is strongly desired for long-term monitoring. Here, we report a fully integrated modular physical, biochemical, and optical sensing platform through a fluidics-routing breadboard, which operates organ-on-a-chip units in a continual, dynamic, and automated manner. We believe that this platform technology has paved a potential avenue to promote the performance of current organ-on-a-chip models in drug screening by integrating a multitude of real-time sensors to achieve automated in situ monitoring of biophysical and biochemical parameters.
Analysis
This paper presents a fully integrated modular sensing platform for organs-on-chips, enabling automated and continual in situ monitoring of organoid behaviors.
Discovery
Mark T. Kozlowski; Christiana Crook; Hsun Teresa Ku
Fuyin Zheng; Yuminghao Xiao; Hui Liu; Yubo Fan; Ming Dao
Caleb Jensen; Yong Teng
Qirui Wu; Jinfeng Liu; Xiaohong Wang; Lingyan Feng; Jinbo Wu; Xiaoli Zhu; Weijia Wen; Xiuqing Gong
Giovanni Giuseppe Giobbe; Claire Crowley; Camilla Luni; Sara Campinoti; Moustafa Khedr; Kai Kretzschmar; Martina M. De Santis; Elisa Zambaiti; Federica Michielin; Laween Meran; Qianjiang Hu; Gijs J. F. van Son; Luca Urbani; Manfredi Anna; Monica Giomo; Simon Eaton; Davide Cacchiarelli; Vivian Li; Hans Clevers; Paola Bonfanti; Nicola Elvassore; Paolo De Coppi
Ruoshi Shi; Nikolina Radulovich; Christine Ng; Geoffrey Liu; Hirotsugu Notsuda; Michael Cabanero; Sebastião N. Martins-Filho; Vibha Raghavan; Quan Li; Arvind Singh Mer; Joshua C. Rosen; Ming Li; Yu-Hui Wang; Laura Tamblyn; Nhu‐An Pham; Benjamin Haibe‐Kains; Geoffrey Liu; Nadeem Moghal; Ming‐Sound Tsao
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