Joshua D. Cohen; Ammar A. Javed; Christopher J. Thoburn; Fay Wong; Jeanne Tie; Peter Gibbs; C. Max Schmidt; Michele Yip-Schneider; Peter J. Allen; Mark Schattner; Randall E. Brand; Aatur D. Singhi; Gloria M. Petersen; Seung‐Mo Hong; Song Cheol Kim; Massimo Falconi; Claudio Doglioni; Matthew J. Weiss; Nita Ahuja; Jin He; Martin A. Makary; Anirban Maitra; Samir Hanash; Marco Dal Molin; Yuxuan Wang; Lu Li; Janine Ptak; Lisa Dobbyn; Joy Schaefer; Natalie Silliman; Maria Popoli; Michael Goggins; Ralph H. Hruban; Christopher L. Wolfgang; Alison P. Klein; Cristian Tomasetti; Nickolas Papadopoulos; Kenneth W. Kinzler; Bert Vogelstein; Anne Marie Lennon · 2017 · Proceedings of the National Academy of Sciences
Paper
Significance Few patients with pancreatic cancer survive longer than 5 y, in part because most patients are identified only after their disease has progressed to an advanced stage. In this study, we show how combining mutations in circulating tumor DNA (ctDNA) with protein markers can result in a screening test with improved sensitivity while retaining specificity. The combination of the ctDNA and protein markers was superior to any single marker. Moreover, the combination detected nearly two-thirds of pancreatic cancers that had no evidence of distant metastasis at the time of surgical resection. The strategy may represent an approach to detect cancers of many types at an earlier stage.
Analysis
This study proposes a liquid biopsy strategy combining circulating tumor DNA (ctDNA) mutations and protein markers to improve the early detection of pancreatic cancer, a disease with low survival rates due to late diagnosis.
Discovery
Hyukjung Kwon; Sun Hye Shin; Hyun Ho Kim; Na Young Min; Yugyeong Lim; T. Joo; Kyoung Joo Lee; Minseon Jeong; Hyojung Kim; Seon-young Yun; Yoon-Hee Kim; Dabin Park; Joungsu Joo; Jin‐Sik Bae; Sunghoon Lee; Byeong‐Ho Jeong; Kyungjong Lee; Hayemin Lee; Hong Kwan Kim; Kyongchol Kim; Sang‐Won Um; Changhyeok An; Min Seob Lee
Christopher Abbosh; Alexander M. Frankell; Thomas Harrison; Judit Kisistók; Aaron T. Garnett; Laura Johnson; Selvaraju Veeriah; Mike Moreau; Adrian Chesh; Tafadzwa L. Chaunzwa; Jakob Weiss; Morgan R. Schroeder; Sophia Ward; Kristiana Grigoriadis; Aamir Shahpurwalla; Kevin Litchfield; Clare Puttick; Dhruva Biswas; Takahiro Karasaki; James R. Black; Carlos Martínez‐Ruiz; Maise Al Bakir; Oriol Pich; Thomas B.K. Watkins; Emilia L. Lim; Ariana Huebner; David A. Moore; Nadia Godin-Heymann; Anne L’Hernault; Hannah Bye; Aaron Odell; Paula Kalavakur; Fábio Gomes; Akshay J. Patel; Elizabeth Manzano; Crispin T. Hiley; Nicolas Carey; Joan Riley; Daniel E. Cook; Darren Hodgson; Daniel Stetson; J. Carl Barrett; Roderik M. Kortlever; Gérard I. Evan; Allan Hackshaw; Robert Daber; Jacqui Shaw; Hugo J.W.L. Aerts; Abel Licon; Josh Stahl; Mariam Jamal‐Hanjani; J.F. Lester; Amrita Bajaj; Apostolos Nakas; Azmina Sodha-Ramdeen; Keng Ang; Mohamad Tufail; Mohammed Fiyaz Chowdhry; Molly Scotland; Rebecca Boyles; Sridhar Rathinam; Claire Wilson; Domenic Marrone; Sean Dulloo; Dean A. Fennell; Gurdeep Matharu; Lindsay Primrose; Ekaterini Boleti; Heather Cheyne; Mohammed S. Khalil; Shirley Richardson; Tracey Cruickshank; Gillian Price; Keith M. Kerr; Sarah Benafif; Kayleigh Gilbert; Babu Naidu; Aya Osman; Christer Lacson; Gerald Langman; Helen Shackleford; Madava Djearaman; Salma Kadiri; Gary Middleton; Angela Leek; Jack Davies Hodgkinson; Nicola Totten; Ángeles Montero; Elaine Smith; Eustace Fontaine; Felice Granato; Helen Doran; Juliette Novasio; Kendadai Rammohan; Leena Dennis Joseph; Paul Bishop; Rajesh Shah; Stuart Moss; Vijay Joshi; Philip Crosbie
Siobhan Connal; James M. Cameron; Alexandra Sala; Paul M. Brennan; David Scott Palmer; Joshua D. Palmer; Haley K. Perlow; Matthew J. Baker
Giovanna Maria Stanfoca Casagrande; Marcela de Oliveira Silva; Rui Manuel Reis; Letícia Ferro Leal
Saife N. Lone; Sabah Nisar; Tariq Masoodi; Mayank Singh; Arshi Rizwan; Sheema Hashem; Wael El‐Rifai; Davide Bedognetti; Surinder K. Batra; Mohammad Haris; Ajaz A. Bhat; Muzafar A. Macha
David L. Crosby; Sangeeta N. Bhatia; Kevin M. Brindle; Lisa M. Coussens; Caroline Dive; Mark Emberton; Sadik C. Esener; Rebecca C. Fitzgerald; Sanjiv S. Gambhir; Peter Kühn; Timothy R. Rebbeck; Shankar Balasubramanian
Source record