Christine E. Brown; Darya Alizadeh; Renate Starr; Lihong Weng; Jamie R. Wagner; Araceli Naranjo; Julie R. Ostberg; M. Suzette Blanchard; Julie Kilpatrick; Jennifer Simpson; Anita Kurien; Saul J. Priceman; Xiuli Wang; Todd L. Harshbarger; Massimo D’Apuzzo; Julie A. Ressler; Michael C. Jensen; Michael E. Barish; Mike Y. Chen; Jana Portnow; Stephen J. Forman; Behnam Badie · 2016 · New England Journal of Medicine
Paper
A patient with recurrent multifocal glioblastoma received chimeric antigen receptor (CAR)-engineered T cells targeting the tumor-associated antigen interleukin-13 receptor alpha 2 (IL13Rα2). Multiple infusions of CAR T cells were administered over 220 days through two intracranial delivery routes - infusions into the resected tumor cavity followed by infusions into the ventricular system. Intracranial infusions of IL13Rα2-targeted CAR T cells were not associated with any toxic effects of grade 3 or higher. After CAR T-cell treatment, regression of all intracranial and spinal tumors was observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid. This clinical response continued for 7.5 months after the initiation of CAR T-cell therapy. (Funded by Gateway for Cancer Research and others; ClinicalTrials.gov number, NCT02208362.).
Analysis
This case study reports the regression of recurrent glioblastoma in a patient treated with IL13Rα2-targeted CAR T-cell therapy delivered via intracranial infusions.
Discovery
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