Research gap
A research opportunity connected to missing evidence, methods, datasets, validation, or translation.
Gap type
Priority
Evidence
Status
Followers
Evidence links
Preparing research brief
The platform is organizing evidence for this page. Linked papers and discussion remain available while the brief is prepared.
The first accepted evidence set for Xenotransplantation includes 12 papers. Evidence currently spans 2014 to 2026. Methods represented in the accepted evidence include Monitoring of creatinine levels, Monitoring of urine output and eGFR, Serial biopsies to assess rejection. The most specific unresolved gap is unresolved evidence gap around single patient case study. Paper intelligence specifically flags: Single patient case study; Study used ex-vivo hearts; Recipients were brain-dead. This gap should be tracked as topic memory, paper intelligence, and future accepted evidence mature.
Current barriers will appear when evidence is linked or reviewed.
Genetically Modified Porcine-to-Human Cardiac Xenotransplantation
Bartley P. Griffith; Corbin E. Goerlich; Avneesh K. Singh; Martine Rothblatt; Christine L. Lau; Aakash Shah; Marc I. Lorber; Alison Grazioli; Kapil Saharia; Susie N. Hong; Susan Joseph; David Ayares; Muhammad M. Mohiuddin · 2022 · New England Journal of Medicine
Progress in Xenotransplantation: Immunologic Barriers, Advances in Gene Editing, and Successful Tolerance Induction Strategies in Pig-To-Primate Transplantation
Daniel Eisenson; Yu Hisadome; Kazuhiko Yamada · 2022 · Frontiers in Immunology
Future work suggestions will appear when the gap has enough evidence.
Possible methods or datasets
Suggest cohorts, benchmarks, validation settings, or datasets that would make this gap testable.
Translational opportunity
Connect the gap to engineering, clinical, or deployment contexts where a stronger answer would matter.
Timeline entries will appear as linked evidence accumulates.
Public discussions linked to this gap will appear here.
Suggest evidence
Add papers or datasets that demonstrate, narrow, or challenge this gap.
Suggest an update
Help refine the gap when new studies change the opportunity.
Follow updates
Save or follow this gap to track how the evidence evolves.
Signal current status
Useful contributions cite evidence, clarify uncertainty, or explain why the object has changed.
Results of Two Cases of Pig-to-Human Kidney Xenotransplantation
Robert A. Montgomery; Jeffrey Stern; Bonnie E. Lonze; Vasishta Tatapudi; Massimo Mangiola; Ming Wu; Elaina Weldon; Nikki Lawson; Cecilia Deterville; Rebecca A. Dieter; Brigitte Sullivan; Gabriella Boulton; Brendan Parent; Greta L. Piper; P. Sommer; Samantha Cawthon; Erin M. Duggan; David Ayares; Amy Dandro; Ana Fazio-Kroll; Maria Kokkinaki; Lars Burdorf; Marc I. Lorber; Jef D. Boeke; Harvey I. Pass; Brendan J. Keating; Adam Griesemer; Nicole Ali; Sameer Mehta; Zoe A. Stewart · 2022 · New England Journal of Medicine
Existing attempts will appear when papers are linked.
Limitations will be summarized from reviewed evidence when available.