Research gap
A research opportunity connected to missing evidence, methods, datasets, validation, or translation.
Gap type
Priority
Evidence
Status
Followers
Evidence links
Preparing research brief
The platform is organizing evidence for this page. Linked papers and discussion remain available while the brief is prepared.
The first accepted evidence set for Liquid Biopsy for Early Cancer Detection includes 12 papers. Evidence currently spans 2020 to 2023. Methods represented in the accepted evidence include Exosome isolation and analysis, Detection of exosome components, Detection of mutations in cfDNA. The most specific unresolved gap is unresolved evidence gap around nafld is often asymptomatic, delaying diagnosis. Paper intelligence specifically flags: NAFLD is often asymptomatic, delaying diagnosis; The technology of liquid biopsies is still evolving; Results need to be further confirmed in future studies. This gap should be tracked as topic memory, paper intelligence, and future accepted evidence mature.
Current barriers will appear when evidence is linked or reviewed.
Advances in methylation analysis of liquid biopsy in early cancer detection of colorectal and lung cancer
Hyukjung Kwon; Sun Hye Shin; Hyun Ho Kim; Na Young Min; Yugyeong Lim; T. Joo; Kyoung Joo Lee; Minseon Jeong; Hyojung Kim; Seon-young Yun; Yoon-Hee Kim; Dabin Park; Joungsu Joo; Jin‐Sik Bae; Sunghoon Lee; Byeong‐Ho Jeong; Kyungjong Lee; Hayemin Lee; Hong Kwan Kim; Kyongchol Kim; Sang‐Won Um; Changhyeok An; Min Seob Lee · 2023 · Scientific Reports
Liquid biopsies: the future of cancer early detection
Siobhan Connal; James M. Cameron; Alexandra Sala; Paul M. Brennan; David Scott Palmer; Joshua D. Palmer; Haley K. Perlow; Matthew J. Baker · 2023 · Journal of Translational Medicine
Future work suggestions will appear when the gap has enough evidence.
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Translational opportunity
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Timeline entries will appear as linked evidence accumulates.
Public discussions linked to this gap will appear here.
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Signal current status
Useful contributions cite evidence, clarify uncertainty, or explain why the object has changed.
Liquid Biopsy for Lung Cancer: Up-to-Date and Perspectives for Screening Programs
Giovanna Maria Stanfoca Casagrande; Marcela de Oliveira Silva; Rui Manuel Reis; Letícia Ferro Leal · 2023 · International Journal of Molecular Sciences
Existing attempts will appear when papers are linked.
Limitations will be summarized from reviewed evidence when available.