Carl H. June; Roddy S. O’Connor; Omkar U. Kawalekar; Saba Ghassemi; Michael C. Milone · 2018 · Science
Paper
Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly advanced from a promising form of immuno-oncology in preclinical models to the recent commercial approvals of chimeric antigen receptor (CAR) T cells to treat leukemia and lymphoma. This Review describes opportunities and challenges for entering mainstream oncology that presently face the CAR T field, with a focus on the challenges that have emerged over the past several years.
Analysis
This review discusses the advancements, opportunities, and challenges of Chimeric Antigen Receptor (CAR) T cell therapy in treating human cancers, particularly leukemia and lymphoma.
Discovery
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