Antigen-presenting nanoparticles for in vivo CAR T cell engineering.

Su FI · 2026 · Nature reviews bioengineering

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Abstract

In vivo cell engineering enables chimeric antigen receptor (CAR) production directly within the body. Most in vivo CAR approaches target broad T cell populations. However, antigen-presenting nanoparticles could be used to engineer specific T cell subsets, leveraging the phenotypic and functional properties of the cells for T cell therapy.

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Publication metadata

Authors: Su FI
Published: Jan 1, 2026
Journal or venue: Nature reviews bioengineering
DOI: 10.1038/s44222-026-00467-x
Paper type: journal article
Source: Pubmed

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