Research gap
A research opportunity connected to missing evidence, methods, datasets, validation, or translation.
Gap type
Priority
Evidence
Status
Followers
Evidence links
Preparing research brief
The platform is organizing evidence for this page. Linked papers and discussion remain available while the brief is prepared.
The first accepted evidence set for Blood Biomarkers for Neurodegeneration includes 12 papers. Evidence currently spans 2017 to 2025. Methods represented in the accepted evidence include Case-control study design, Measurement of NfL concentrations in plasma, Measurement of neurofilament light (NfL) in CSF and blood. The most specific unresolved gap is unresolved evidence gap around retrospective nature of the study. Paper intelligence specifically flags: Retrospective nature of the study; Convenience sample of participants; Potential for unmeasured confounding factors. This gap should be tracked as topic memory, paper intelligence, and future accepted evidence mature.
Current barriers will appear when evidence is linked or reviewed.
Alzheimer's disease neuropathology and its estimation with fluid and imaging biomarkers
Dietmar Rudolf Thal; Koen Poesen; Rik Vandenberghe; Steffi De Meyer · 2025 · Molecular Neurodegeneration
Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology
Nicholas J. Ashton; Wagner S. Brum; Guglielmo Di Molfetta; Andréa Lessa Benedet; Burak Arslan; Erin M. Jonaitis; Rebecca E. Langhough; Karly Alex Cody; Rachael E. Wilson; Cynthia M. Carlsson; Eugeen Vanmechelen; Laia Montoliu‐Gaya; Juan Lantero‐Rodriguez; Nesrine Rahmouni; Cécile Tissot; Jenna Stevenson; Stijn Servaes; Joseph Therriault; Tharick A. Pascoal; Alberto Lleó; Daniel Alcolea; Juan Fortea; Pedro Rosa‐Neto; Sterling C. Johnson; Andreas Jeromin; Kaj Blennow; Henrik Zetterberg · 2024 · JAMA Neurology
Future work suggestions will appear when the gap has enough evidence.
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Timeline entries will appear as linked evidence accumulates.
Public discussions linked to this gap will appear here.
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Useful contributions cite evidence, clarify uncertainty, or explain why the object has changed.
Blood biomarkers and neurodegeneration in individuals exposed to repetitive head impacts
Charles Bernick; Guogen Shan; Aaron Ritter; Nicholas J. Ashton; Kaj Blennow; Juan Lantero‐Rodriguez; Anniina Snellman; Henrik Zetterberg · 2023 · Alzheimer s Research & Therapy
Existing attempts will appear when papers are linked.
Limitations will be summarized from reviewed evidence when available.