Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates

Chia‐Han Chiang; Sang Min Won; Amy L. Orsborn; Ki Jun Yu; Michael Trumpis; Brinnae Bent; Charles Wang; Yeguang Xue; Seunghwan Min; Virginia Woods; Chunxiu Yu; Bong Hoon Kim; Sung Bong Kim; Rizwan Huq; Jinghua Li; Kyung Jin Seo; Flavia Vitale; Andrew G. Richardson; Hui Fang; Yonggang Huang; Kenneth L. Shepard; Bijan Pesaran; John A. Rogers; Jonathan Viventi · 2020 · Science Translational Medicine

Paper

Abstract

Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating powered electronics to multiplex many electrodes to a few external wires. However, existing multiplexed electrode arrays rely on encapsulation strategies that have limited implant lifetimes. Here, we developed a flexible, multiplexed electrode array, called "Neural Matrix," that provides stable in vivo neural recordings in rodents and nonhuman primates. Neural Matrix lasts over a year and samples a centimeter-scale brain region using over a thousand channels. The long-lasting encapsulation (projected to last at least 6 years), scalable device design, and iterative in vivo optimization described here are essential components to overcoming current hurdles facing next-generation neural technologies.

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This paper presents the 'Neural Matrix,' a flexible, multiplexed electrode array designed for stable, high-resolution, long-term neural recordings in rodents and nonhuman primates.

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Source record

Publication metadata

Authors: Chia‐Han Chiang; Sang Min Won; Amy L. Orsborn; Ki Jun Yu; Michael Trumpis; Brinnae Bent; Charles Wang; Yeguang Xue; Seunghwan Min; Virginia Woods; Chunxiu Yu; Bong Hoon Kim; Sung Bong Kim; Rizwan Huq; Jinghua Li; Kyung Jin Seo; Flavia Vitale; Andrew G. Richardson; Hui Fang; Yonggang Huang; Kenneth L. Shepard; Bijan Pesaran; John A. Rogers; Jonathan Viventi
Published: Apr 8, 2020
Journal or venue: Science Translational Medicine
DOI: 10.1126/scitranslmed.aay4682
Paper type: journal article
Source: Openalex

DOI OpenAlex