Yoonseok Park; Colin K. Franz; Hanjun Ryu; Haiwen Luan; Kristen Y. Cotton; Jong Uk Kim; Ted S. Chung; Shiwei Zhao; Abraham Vázquez‐Guardado; Da Som Yang; Kan Li; Raudel Avila; Jack Phillips; Maria J. Quezada; Hokyung Jang; Sung Soo Kwak; Sang Min Won; Kyeongha Kwon; Hyoyoung Jeong; Amay J. Bandodkar; Mengdi Han; Hangbo Zhao; Gabrielle R. Osher; Heling Wang; KunHyuck Lee; Yihui Zhang; Yonggang Huang; John D. Finan; John A. Rogers · 2021 · Science Advances
Paper
Three-dimensional (3D), submillimeter-scale constructs of neural cells, known as cortical spheroids, are of rapidly growing importance in biological research because these systems reproduce complex features of the brain in vitro. Despite their great potential for studies of neurodevelopment and neurological disease modeling, 3D living objects cannot be studied easily using conventional approaches to neuromodulation, sensing, and manipulation. Here, we introduce classes of microfabricated 3D frameworks as compliant, multifunctional neural interfaces to spheroids and to assembloids. Electrical, optical, chemical, and thermal interfaces to cortical spheroids demonstrate some of the capabilities. Complex architectures and high-resolution features highlight the design versatility. Detailed studies of the spreading of coordinated bursting events across the surface of an isolated cortical spheroid and of the cascade of processes associated with formation and regrowth of bridging tissues across a pair of such spheroids represent two of the many opportunities in basic neuroscience research enabled by these platforms.
Analysis
This paper introduces microfabricated 3D frameworks as compliant, multifunctional neural interfaces for studying 3D neural constructs like cortical spheroids and assembloids.
Discovery
Matthias Dold; Joana Pereira; Bastian Sajonz; Volker A Coenen; Jordy Thielen; Marcus L F Janssen; Michael Tangermann
MoonHyung Jang; M.T. Hays; Wei-Han Yu; Changuk Lee; P. Caragiulo; Athanasios T. Ramkaj; Pingyu Wang; AJ Phillips; Nicholas Vitale; Pulkit Tandon; Pumiao Yan; Pui‐In Mak; Youngcheol Chae; E. J. Chichilnisky; Boris Murmann; Dante G. Muratore
Jing Mang; Zhuo Xu; YingBin Qi; Ting Zhang
MoonHyung Jang; Wei-Han Yu; Changuk Lee; M.T. Hays; Pingyu Wang; Nick Vitale; Pulkit Tandon; Pumiao Yan; Pui‐In Mak; Youngcheol Chae; E. J. Chichilnisky; Boris Murmann; Dante G. Muratore
Zheng Zhang; Timothy G Constandinou
Navneet Tibrewal; Nikki Leeuwis; Maryam Alimardani
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