Research gap
A research opportunity connected to missing evidence, methods, datasets, validation, or translation.
Gap type
Priority
Evidence
Status
Followers
Evidence links
Preparing research brief
The platform is organizing evidence for this page. Linked papers and discussion remain available while the brief is prepared.
The first accepted evidence set for CAR-T and engineered T cell therapies includes 12 papers. Evidence currently spans 2018 to 2023. Methods represented in the accepted evidence include Synthetic immunity, T-cell engineering, Phase 1 clinical trial. The most specific unresolved gap is unresolved evidence gap around antigen escape. Paper intelligence specifically flags: Antigen escape; Neurologic dysfunction; Cytokine release syndrome. This gap should be tracked as topic memory, paper intelligence, and future accepted evidence mature.
Current barriers will appear when evidence is linked or reviewed.
TCR-engineered T cell therapy in solid tumors: State of the art and perspectives
Estelle Baulu; Célia Gardet; Nicolas Chuvin; Stéphane Depil · 2023 · Science Advances
CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome
Silvia Arcangeli; Camilla Bove; Claudia Mezzanotte; Barbara Camisa; Laura Falcone; Francesco Manfredi; Eugenia Bezzecchi; Rita El Khoury; Rossana Norata; Francesca Sanvito; Maurilio Ponzoni; Beatrice Greco; Marta Angiola Moresco; Matteo G. Carrabba; Fabio Ciceri; Chiara Bonini; Attilio Bondanza; Monica Casucci · 2022 · Journal of Clinical Investigation
Future work suggestions will appear when the gap has enough evidence.
Possible methods or datasets
Suggest cohorts, benchmarks, validation settings, or datasets that would make this gap testable.
Translational opportunity
Connect the gap to engineering, clinical, or deployment contexts where a stronger answer would matter.
Timeline entries will appear as linked evidence accumulates.
Public discussions linked to this gap will appear here.
Suggest evidence
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Suggest an update
Help refine the gap when new studies change the opportunity.
Follow updates
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Signal current status
Useful contributions cite evidence, clarify uncertainty, or explain why the object has changed.
CAR-T cell therapy: current limitations and potential strategies
Robert C. Sterner; Rosalie M. Sterner; Rosalie M. Sterner; Rosalie M. Sterner · 2021 · Blood Cancer Journal
Existing attempts will appear when papers are linked.
Limitations will be summarized from reviewed evidence when available.